A canonical microcircuit for estimating Excitation/ Inhibition (E/I) balance

Abstract

Excitation/inhibition (E/I) balance is crucial for maintaining healthy brain function and can be disrupted in various neurological and psychiatric disorders. Despite its importance, there are few tools to stu...

Quantum mechanics has been used to explain mesoscale properties in condensed matter physics. Our latest perspective "Testing quantum-like markers in neural dynamics" published in J. Comput. Neurosci. asks if we can detect signatures of quantum effects in mesoscale brain dynamics. Abstract ...

Our latest  work with MIT colleagues was featured in the Picower Institute's News Website. Read it here.

A new study adds evidence that electric fields in the brain help to organize and shape underlying neural activity via “ephaptic coupling.” You can access the MIT Picower news piece and paper here. Abstract below:

 The waxing and waning cortical oscillatory power correla...

In a recent Biological Psychiatry paper with UCL and other colleagues, we found that reduced pyramidal cell excitability is present at baseline in clinical high risk for psychosis (CHR) converters, consistent with the hypothesis that hypofunction of pyramidal cells is a primary pathol...