Hypofunction of pyramidal cells seems to be a primary pathology in schizophrenia
In a recent Biological Psychiatry paper with UCL and other colleagues, we found that reduced pyramidal cell excitability is present at baseline in clinical high risk for psychosis (CHR) converters, consistent with the hypothesis that hypofunction of pyramidal cells is a primary pathology in schizophrenia rather than a consequence of chronic illness. We also found that positive symptoms among CHR-converters may reflect compensatory downregulation of inhibition, see also here for a previous, free version of the same paper.
